Antibiotic Susceptibility Evaluation of Bacterial Agents Causing Infection in Children with Acute Tonsillopharyngitis
Hamidreza Sherkatolabbasieh1, Majid Firouzi1, Shiva Shafizadeh2
1Department of Pediatrics, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Insights
This study found that a higher clinical score increases the likelihood of a positive throat culture for group A beta-hemolytic pharyngitis. All tested antibiotics showed sensitivity against the bacteria.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Medicine
Background:
- Group A beta-hemolytic pharyngitis is a common infection.
- Antibiotic resistance is a growing concern in treating bacterial infections.
Purpose of the Study:
- To determine the prevalence of group A beta-hemolytic pharyngitis.
- To assess antibiotic resistance and sensitivity patterns of group A beta-hemolytic Streptococcus.
- To evaluate the correlation between clinical scores and culture outcomes.
Main Methods:
- A cross-sectional study involving 170 patients aged 3-15 with sore throat.
- Clinical data collection and scoring using the McIssac score.
- Antimicrobial susceptibility testing using the disk diffusion method against key antibiotics.
Main Results:
- Amoxicillin exhibited the highest resistance rate (5%).
- All bacterial isolates demonstrated sensitivity to amoxicillin, cephalexin, cefazolin, and erythromycin.
- A higher McIssac score correlated with increased likelihood of positive throat cultures, showing 75% sensitivity and 94.8% negative predictive value.
Conclusions:
- Clinical scoring is a valuable tool in diagnosing group A beta-hemolytic streptococcal pharyngitis.
- Current antibiotic regimens remain effective, but ongoing monitoring for resistance is crucial.
Background:
The aim of this study is to evaluate the prevalence of group A beta-hemolytic pharyngitis by assessing the outcome of the culture and the resistance and sensitivity of group A beta hemolytic Streptococcus to antibiotics.
Methods:
This cross-sectional study was conducted on 170 patients aged 3-15 years, referred to the clinic with complaints of sore throat. Patients' history was collected and physical examination was performed and was score based on clinical findings. Patients with other underlying pathologies and those taking antibiotics prior to the study were excluded from our study. Antimicrobial susceptibility test was performed by disk diffusion method against cephalexin, cefazolin, erythromycin and amoxicillin.
Results:
A total of 170 patients were reported with sore throat. Patients with positive culture results were 60% male and 40% female. Amoxicillin resistance was the greatest (5%) in the culture. All isolated bacteria were sensitive to amoxicillin, cephalexin, cefazolin and erythromycin. Patients with McIssac score ≥ 6 showed clinical sensitivity 75% specificity 61% negative predictive value 94.8% and positive predictive value 20.3% for Group A beta-hemolytic streptococcal pharyngitis.
Conclusion:
The results showed the higher the clinical score, the greater the chance of positive throat culture.
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