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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Cutaneous Leishmaniasis Treated with Miltefosine: A Case Series of 10 Paediatric Patients

Ayelet Ollech1, Michal Solomon, Amir Horev

  • 1Department of Dermatology, Rabin Medical Center, Beilinson Hospital Petach Tikva, Petach Tikva 49100, Israel.

Acta Dermato-Venereologica
|November 18, 2020
PubMed

Insights

Miltefosine shows promise as an effective and safe oral treatment for pediatric Old World cutaneous leishmaniasis. This study found an 80% complete response rate in children with Leishmania tropica or Leishmania major infections.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Tropical Medicine

Background:

  • Cutaneous leishmaniasis presents significant treatment challenges in children.
  • Old World cutaneous leishmaniasis requires effective and safe therapeutic options for pediatric patients.

Purpose of the Study:

  • To evaluate the efficacy and safety of miltefosine for treating Old World cutaneous leishmaniasis in children.
  • To assess treatment outcomes in pediatric patients with Leishmania tropica and Leishmania major infections.

Main Methods:

  • A multicenter retrospective review was conducted on 10 pediatric patients (≤18 years) treated with miltefosine in Israel.
  • Data collected included patient age, Leishmania species, treatment duration, follow-up period, treatment response, and adverse effects.

Main Results:

  • Complete response to miltefosine was observed in 80% (8/10) of pediatric patients.
  • Treatment failure occurred in 20% (2/10) of cases.
  • Adverse effects associated with miltefosine treatment were minimal.

Conclusions:

  • Oral miltefosine appears to be an effective and safe treatment option for pediatric Old World cutaneous leishmaniasis caused by Leishmania tropica or Leishmania major.
  • Further research is necessary to definitively establish miltefosine's role in treating pediatric cutaneous leishmaniasis.

Keywords:
Leishmania majorLeishmania tropicaamphotericin Bmiltefosinesodium stibogluconateleishmaniasis

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