[S100B level and cognitive dysfunction after robotic-assisted laparoscopic radical prostatectomy procedures: a...

Area of Science:

• Neurosurgery
• Anesthesiology
• Biochemistry

Background:

• Robotic-assisted laparoscopic radical prostatectomy (RALRP) is a common procedure.
• Postoperative Cognitive Dysfunction (POCD) is a potential complication after surgery.
• The role of serum S100B as a biomarker for POCD requires further investigation.

Purpose of the Study:

• To investigate the association between serum S100B levels and POCD after RALRP.
• To identify factors contributing to POCD development in patients undergoing RALRP.

Main Methods:

• 82 patients undergoing RALRP were included in the study.
• Serum S100B levels were measured preoperatively and at multiple time points postoperatively.
• Neuropsychological testing was used to assess cognitive function at baseline and postoperatively.

Main Results:

• 29% of patients exhibited POCD at 7 days and 11% at 3 months post-surgery.
• Significantly elevated serum S100B levels were observed in patients with POCD.
• Longer duration of anesthesia and Trendelenburg positioning were associated with POCD development.

Conclusions:

• Increased S100B levels post-RALRP are associated with POCD.
• Anesthesia and Trendelenburg duration are significant contributors to POCD.
• S100B may serve as a potential biomarker for predicting POCD after RALRP.