Related Experiment Video
Updated: Nov 29, 2025
08:48
Demonstration of Spin-Multiplexed and Direction-Multiplexed All-Dielectric Visible Metaholograms
Published on: September 25, 2020
6.1K
Integrated Molar Chiral Sensing Based on High-Q Metasurface
Yang Chen1, Chen Zhao1,2, Yongzhe Zhang2
1Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117583, Singapore.
Nano Letters
|November 20, 2020
Summary
This study introduces a novel metasurface for simultaneous circular dichroism (CD) spectroscopy and molar concentration measurement. This integrated approach enhances chiral analysis sensitivity and simplifies measurements for academic and industrial applications.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Materials Science
Background:
- Circular dichroism (CD) spectroscopy is crucial for analyzing chiral molecules in academia and industry.
- Metasurfaces enhance CD spectroscopy sensitivity but require separate molar concentration measurements.
- Current methods lack integrated chiral sensing capabilities, necessitating multi-platform analysis.
Purpose of the Study:
- To develop an integrated metasurface for simultaneous CD spectrum and molar concentration acquisition.
- To enhance the sensitivity and accuracy of chiral molecule analysis.
- To establish a streamlined procedure for molar chiral sensing.
Main Methods:
- Utilized high-Q resonances supported by bound states in the continuum on a metasurface.
- Generated a superchiral field for significant CD signal enhancement.
- Employed refractive index-based detection for molar concentration measurement.
Main Results:
- Achieved a 59-fold enhancement in CD signal.
- Obtained a large figure-of-merit of 80.6 for refractive index-based molar concentration detection.
- Demonstrated the first integrated acquisition of CD spectrum and molar concentration on a single metasurface.
Conclusions:
- The developed metasurface enables highly sensitive, integrated molar chiral sensing.
- This advancement simplifies chiral analysis by combining spectral and concentration measurements.
- The findings offer a new standard procedure for sensitive chiral molecule quantification.
Related Concept Videos
02:25Chirality
28.4K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
28.4K
02:25Molecules with Multiple Chiral Centers
14.4K
Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
14.4K
02:30Chirality in Nature
16.1K
Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
16.1K
00:58¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons
2.9K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
2.9K
00:58¹H NMR Signal Integration: Overview
2.9K
The intensity of a signal, which can be represented by the area under the peak, depends on the number of protons contributing to that signal. The area under each peak is shown as a vertical line called an integral, with the integral value listed under it, as seen in the proton NMR spectrum of benzyl acetate. Each integral value is divided by the smallest integral value to obtain the ratio of the number of protons producing each signal. The ratio reveals the relative number of protons and not...
2.9K