RIFM fragrance ingredient safety assessment, 3-octanol, CAS Registry Number 589-98-0

Area of Science:

• Toxicology and Environmental Safety Assessment

Background:

• 3-Octanol is a chemical compound used in various applications.
• Comprehensive safety data is essential for regulatory compliance and consumer protection.

Purpose of the Study:

• To evaluate the safety of 3-octanol across multiple toxicological endpoints.
• To assess environmental safety based on PBT criteria and risk quotients.

Main Methods:

• Utilized read-across data from analogs 3-hexanol and 2-octanol for genotoxicity and reproductive toxicity.
• Calculated Margin of Exposure (MOE) for repeated dose and reproductive toxicity.
• Assessed phototoxicity/photoallergenicity via UV spectra.
• Applied Threshold of Toxicological Concern (TTC) for local respiratory toxicity.
• Evaluated environmental safety against IFRA standards and PEC/PNEC ratios.

Main Results:

• 3-Octanol is not expected to be genotoxic, phototoxic, or photoallergenic.
• Calculated MOE >100 for repeated dose and reproductive toxicity, indicating safety.
• No safety concerns for skin sensitization at current use levels.
• 3-Octanol is not Persistent, Bioaccumulative, and Toxic (PBT).
• Environmental risk quotients (PEC/PNEC) are <1.

Conclusions:

• The existing data support the safe use of 3-octanol as described.
• No toxicological or environmental safety concerns were identified under current declared use levels.