Related Experiment Video
Updated: Nov 29, 2025
Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
Published on: May 24, 2021
Cardiac Magnetic Resonance Quantification of Structure-Function Relationships in Heart Failure
Kim-Lien Nguyen1, Peng Hu2, J Paul Finn2
1Division of Cardiology, David Geffen School of Medicine at UCLA, VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Diagnostic Cardiovascular Imaging Research Laboratory, Department of Radiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Physics & Biology in Medicine Graduate Program, University of California, Los Angeles, Los Angeles, CA, USA.
Abstract:
Classification of heart failure is based on the left ventricular ejection fraction (EF): preserved EF, midrange EF, and reduced EF. There remains an unmet need for further heart failure phenotyping of ventricular structure-function relationships. Because of high spatiotemporal resolution, cardiac magnetic resonance (CMR) remains the reference modality for quantification of ventricular contractile function. The authors aim to highlight novel frameworks, including theranostic use of ferumoxytol, to enable more efficient evaluation of ventricular function in heart failure patients who are also frequently anemic, and to discuss emerging quantitative CMR approaches for evaluation of ventricular structure-function relationships in heart failure.
