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[Quinidine-induced lichenoid photodermatitis].

J M Bonnetblanc1, P Bernard, G Catanzano

  • 1Service de Dermatologie, CHU Dupuytren, Limoges.

Annales De Dermatologie Et De Venereologie
|January 1, 1987
PubMed
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Quinidine can cause lichenoid photodermatitis, a skin reaction appearing on sun-exposed areas. This condition often improves after discontinuing quinidine or hydroquinidine.

Area of Science:

  • Dermatology
  • Photodermatology
  • Clinical Toxicology

Background:

  • Quinidine-induced lichenoid photodermatitis was first identified in 1982.
  • This condition presents as a distinct clinical presentation affecting sun-exposed skin.

Observation:

  • Four adult patients (2 male, 2 female) aged 60-81 presented with varied skin eruptions.
  • Lesions included lichenoid, eczematous, desquamative, and bullous forms, predominantly on sun-exposed areas and worsening in summer.
  • Patients had cardiovascular histories, with comorbidities like diabetes and hypertension.

Findings:

  • Three patients showed rapid improvement upon withdrawal of quinidine or hydroquinidine.
  • Histopathology confirmed lichenoid eruptions, with immunopathology revealing pemphigoid-like or lichen planus-suggestive patterns.

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  • One patient experienced prolonged disease with pigmented sequelae.

    • Implications:

    • Quinidine is identified as a common causative agent for drug-induced lichenoid reactions.
    • The findings highlight the varied clinical and histopathological presentations of quinidine-induced photodermatitis.
    • Early recognition and drug withdrawal are crucial for managing this adverse drug reaction.