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Impact Of Feeding Practice On Diversity Pattern Of The Gut Microbiome In Infants

Mehwish Durrani1, Rubina Nazli2, Sadia Fatima2

  • 1Institute of Basicx Medical Sciences, Khyber Medical University, Peshawar, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC
|November 23, 2020
PubMed

Insights

Infant feeding practices significantly impact gut microbiota diversity. Formula-fed infants show higher levels of Firmicutes, while breast-fed infants have more Selenomonadales and Streptococcus salivarius.

Area of Science:

  • Microbiology
  • Pediatrics
  • Gastroenterology

Background:

  • The infant gut microbiome is established early and influences lifelong health.
  • Feeding practices are a key determinant of infant gut microbiota composition.
  • Understanding these early microbial shifts is crucial for child health.

Purpose of the Study:

  • To investigate the effect of feeding practices on infant gut microbiota diversity.
  • To compare the gut microbial composition between breast-fed and formula-fed infants in a Pakistani cohort.

Main Methods:

  • Cross-sectional study of 46 healthy infants (0-4 months) in Peshawar.
  • Stool samples collected from breast-fed (BF) and formula-fed (FF) infants.
  • Next-generation sequencing used for DNA analysis of gut microbiota.

Main Results:

  • Phylum Firmicutes was significantly more abundant in formula-fed infants (p=0.001).
  • Bacilli, Streptococcaceae, and Streptococcus were higher in formula-fed infants.
  • Selenomonadales and Streptococcus salivarius were significantly higher in breast-fed infants (p<0.05).

Conclusions:

  • Feeding method profoundly shapes the initial infant gut microbiome.
  • Firmicutes, Bacilli, Streptococcaceae, and Streptococcus characterize formula-fed infant gut flora.
  • Selenomonadales and Streptococcus salivarius are associated with breast-fed infant gut flora.
Abstract

Keywords:
Gut microbiota; Breast-fed infants; Formula-fed infantsNext generation sequencing

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