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Updated: Nov 29, 2025

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Two-Dimensional Material-Based Biosensors for Virus Detection.

Cécilia Ménard-Moyon1, Alberto Bianco1, Kourosh Kalantar-Zadeh2

  • 1CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR3572, University of Strasbourg, ISIS, Strasbourg 67000, France.

ACS Sensors
|November 23, 2020
PubMed
Summary
This summary is machine-generated.

Two-dimensional materials (2DMs) offer a promising solution for rapid, low-cost virus detection. These advanced materials enable highly sensitive and selective biosensors crucial for combating viral infections and pandemics.

Keywords:
antibodydiagnosisgraphenemetal−organic frameworksmolybdenum disulfidenucleic acidsproteinstransducers

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Viral infections cause significant global mortality and economic losses.
  • Current virus detection methods often suffer from inaccuracies, high costs, and slow response times.
  • There is a critical need for accessible, point-of-care diagnostic systems for timely infection management.

Purpose of the Study:

  • To provide a comprehensive review of two-dimensional material (2DM)-based biosensors for virus detection.
  • To explore the advantages and drawbacks of 2DM biosensors in diagnosing viral infections.
  • To offer insights for future research and development in 2DM biosensor technology for pandemic prevention.

Main Methods:

  • Review of existing literature on 2DM biosensors for viral detection.
  • Analysis of the physicochemical properties of 2DMs relevant to biosensing.
  • Discussion of functionalization strategies for enhanced viral recognition.

Main Results:

  • 2DMs possess unique properties ideal for developing highly sensitive and selective virus biosensors.
  • Functionalization of 2DMs with biomolecules enables specific virus identification, even at early stages.
  • 2DM biosensors offer potential for fast, accurate, and multiplexed detection of various viruses and strains.

Conclusions:

  • 2DM-based biosensors represent a significant advancement for efficient virus detection, addressing limitations of conventional methods.
  • Further research into 2DM interactions with viruses and functionalization techniques will drive the development of next-generation diagnostic tools.
  • These advanced biosensors are vital for early detection, disease management, and the prevention of future viral pandemics.