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Roxithromycin in skin and soft tissue infections.
P Agache1, P Amblard, G Moulin
1University Department of Dermatology, Hôpital St-Jacques, Besançon, France.
The Journal of Antimicrobial Chemotherapy
|November 1, 1987
Summary
Roxithromycin and doxycycline showed similar effectiveness in treating skin infections. Both antibiotics achieved 92% clinical and bacteriological success rates in this randomized trial.
Area of Science:
- Dermatology
- Infectious Diseases
- Pharmacology
Background:
- Skin infections are common conditions requiring effective antibiotic treatment.
- Assessing the comparative efficacy of different antibiotic agents is crucial for clinical practice.
Purpose of the Study:
- To compare the clinical and bacteriological effectiveness of roxithromycin and doxycycline in patients with infected skin conditions.
Main Methods:
- A double-blind, randomized investigation involving 76 patients.
- Patients were treated with either roxithromycin (150 mg twice daily) or doxycycline (200 mg once daily).
- Groups were well-matched for demographic and clinical characteristics.
Main Results:
- Roxithromycin demonstrated a 92% clinical and 92% bacteriological effectiveness.
- Doxycycline showed an 82% clinical and 82% bacteriological effectiveness.
- The observed differences in effectiveness between the two antibiotics were not statistically significant.
Conclusions:
- Roxithromycin and doxycycline exhibit comparable efficacy in treating infected skin conditions.
- Both antibiotics represent viable therapeutic options for managing bacterial skin infections.