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Related Experiment Video

Updated: Nov 28, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Continuous facial myokymia in multiple sclerosis.

Jordan L Clay1, Mauricio F Villamar2,3

  • 1Department of Neurology University of Virginia Health Systems Charlottesville VA USA.

Clinical Case Reports
|November 25, 2020
PubMed
Summary

Facial myokymia, a twitching of facial muscles, can signal demyelinating lesions. In multiple sclerosis patients, acute facial myokymia may indicate an active lesion with localizing value.

Keywords:
brainstemfacial myokymiamovement disordersmultiple sclerosis

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Area of Science:

  • Neurology
  • Clinical Neuroscience

Background:

  • Facial myokymia is a rare neurological sign characterized by undulating, continuous, or episodic contractions of facial muscles.
  • It can be associated with various neurological conditions, including demyelinating diseases.

Purpose of the Study:

  • To highlight the significance of acute-onset continuous facial myokymia as a potential indicator of active demyelinating lesions.
  • To discuss the localizing value of facial myokymia in the context of multiple sclerosis.

Main Methods:

  • Case report presentation.
  • Clinical observation and neurological examination.
  • Review of relevant literature on facial myokymia and demyelinating lesions.

Main Results:

  • The patient presented with acute-onset continuous facial myokymia.
  • This symptom was associated with multiple sclerosis, a demyelinating disease.
  • The facial myokymia was considered indicative of an active demyelinating lesion.

Conclusions:

  • Acute-onset continuous facial myokymia can serve as a valuable clinical sign in diagnosing active lesions in patients with multiple sclerosis.
  • Recognizing facial myokymia's potential link to demyelination aids in neurological localization and patient management.