Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Default-mode network activity is retained in the isolated hemisphere of people after hemispherotomy.

Brain communications·2026

Same author

Mechanical Thrombectomy for M2 versus M1 Occlusions: A Propensity-Matched Analysis With Severity-Stratified Assessment of Early Neurological Improvement.

AJNR. American journal of neuroradiology·2026

Same author

Clinical MR Biomarkers.

Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer·2026

Same author

APTw CEST MRI in therapy-naive IDH-wildtype glioblastoma: insights into tumor heterogeneity and molecular subtypes.

Journal of neuro-oncology·2026

Same author

Type, severity, frequency and management of adverse reactions associated with ultrasound contrast agents: a systematic review and meta-analysis.

European radiology·2026

Same author

Proof of concept: Portable ultra-low-field MRI for the assessment of brain tumors.

Neuro-oncology practice·2026

Same journal

Cardiovascular Magnetic Resonance: Innovation, Integration, and Clinical Impact.

Magnetic resonance imaging clinics of North America·2026

Same journal

Advances and Innovations in Cardiovascular Magnetic Resonance.

Magnetic resonance imaging clinics of North America·2026

Same journal

The Future of Cardiac Magnetic Resonance: Navigating Ultra-High and Low-Field Imaging (Part 2).

Magnetic resonance imaging clinics of North America·2026

Same journal

Artificial Intelligence Applications in Cardiac MR Imaging.

Magnetic resonance imaging clinics of North America·2026

Same journal

Climate Change and Globally Sustainable Cardiovascular Magnetic Resonance.

Magnetic resonance imaging clinics of North America·2026

Same journal

Strain Imaging in Heart Failure.

Magnetic resonance imaging clinics of North America·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 28, 2025

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

Dynamic Glucose-Enhanced MR Imaging.

Daniel Paech¹, Alexander Radbruch²

¹Division of Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany.

Magnetic Resonance Imaging Clinics of North America

|November 25, 2020

Summary

This summary is machine-generated.

Dynamic glucose-enhanced MRI uses natural d-glucose as a safe, biodegradable contrast agent. This novel approach avoids toxic chemical labels found in conventional medical imaging like CT, PET, and standard MRI.

Keywords:

Chemical exchange saturation transfer (CEST)Chemical exchange-sensitive spin-lock (CESL)GlucoCESL GlucoCEST Glucose-enhanced MR imaging MR biomarkers

More Related Videos

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Related Experiment Videos

Last Updated: Nov 28, 2025

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model

Published on: April 18, 2015

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring

Published on: December 9, 2010

Area of Science:

Medical Imaging
Biochemistry
Radiology

Background:

Conventional medical imaging relies on chemically labeled contrast agents (e.g., iodine, radioisotopes, gadolinium).
These agents enhance signal contrast for visualizing tissues but can pose toxicity risks.
There is a need for safer, more natural contrast agents in medical imaging.

Purpose of the Study:

To introduce and describe dynamic glucose-enhanced (DGE) MR imaging as a novel imaging technique.
To highlight the use of natural, unlabeled d-glucose as a contrast agent.
To present an alternative to conventional, chemically labeled contrast agents.

Main Methods:

Utilizing chemical exchange-sensitive magnetic resonance imaging (MRI) approaches.
Employing natural, unlabeled d-glucose as the contrast agent.
Implementing dynamic imaging protocols to capture glucose uptake and distribution.

Main Results:

Demonstrated the feasibility of using d-glucose as a contrast agent in MRI.
Showcased d-glucose as a nontoxic and biodegradable alternative.
Enabled visualization of tissue compartments and features through glucose enhancement.

Conclusions:

Dynamic glucose-enhanced MRI offers a novel, safer approach to medical imaging.
Natural d-glucose serves as an effective, non-toxic contrast agent.
This technique has potential for various diagnostic applications without chemical labeling concerns.