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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Published on: January 28, 2014

Clinical MR Biomarkers.

Daniel Paech1,2, Sebastian Regnery3, Heinz-Peter Schlemmer4

  • 1Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. dpaech@bwh.harvard.edu.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|May 21, 2026
PubMed
Summary
This summary is machine-generated.

Noninvasive magnetic resonance imaging (MRI) techniques offer valuable diagnostic insights, especially in oncology. This chapter explores established and novel MR biomarkers for clinical use, highlighting their noninvasive advantages.

Keywords:
Chemical Exchange Saturation Transfer (CEST)Diffusion-weighted Imaging (DWI)MR biomarkersMetabolic MRI and SpectroscopyPerfusion-weighted ImagingUltra-high field MRIpH

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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
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Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development

Published on: April 15, 2013

Area of Science:

  • Radiology
  • Oncology
  • Biomarkers

Background:

  • Noninvasive magnetic resonance imaging (MRI) is gaining clinical traction.
  • Imaging biomarkers offer noninvasive advantages over biochemical or histological markers.
  • MRI provides superior spatial and temporal resolution for diagnostic applications.

Purpose of the Study:

  • To review clinical applications of novel MR biomarkers in humans.
  • To focus on the utility of these biomarkers in oncologic diseases.
  • To cover both established and emerging MRI techniques.

Main Methods:

  • Review of clinical applications of established MR biomarkers.
  • Exploration of novel MRI techniques with high clinical potential.
  • Focus on human studies, particularly in oncology.

Main Results:

  • Established MR biomarkers (parts 1-4) are clinically validated.
  • Novel MRI techniques (parts 5-7) show significant potential for clinical utility.
  • Evidence supports the value of MRI biomarkers in diagnostic radiology.

Conclusions:

  • Noninvasive MRI biomarkers are crucial for modern diagnostic radiology.
  • MR biomarkers, especially in oncology, offer significant clinical advantages.
  • Continued development of MRI techniques promises further diagnostic advancements.