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Clinical MR Biomarkers
Daniel Paech1,2, Sebastian Regnery3, Heinz-Peter Schlemmer4
1Division of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. dpaech@bwh.harvard.edu.
Noninvasive magnetic resonance imaging (MRI) techniques offer valuable diagnostic insights, especially in oncology. This chapter explores established and novel MR biomarkers for clinical use, highlighting their noninvasive advantages.
Area of Science:
- Radiology
- Oncology
- Biomarkers
Background:
- Noninvasive magnetic resonance imaging (MRI) is gaining clinical traction.
- Imaging biomarkers offer noninvasive advantages over biochemical or histological markers.
- MRI provides superior spatial and temporal resolution for diagnostic applications.
Purpose of the Study:
- To review clinical applications of novel MR biomarkers in humans.
- To focus on the utility of these biomarkers in oncologic diseases.
- To cover both established and emerging MRI techniques.
Main Methods:
- Review of clinical applications of established MR biomarkers.
- Exploration of novel MRI techniques with high clinical potential.
- Focus on human studies, particularly in oncology.
Main Results:
- Established MR biomarkers (parts 1-4) are clinically validated.
- Novel MRI techniques (parts 5-7) show significant potential for clinical utility.
- Evidence supports the value of MRI biomarkers in diagnostic radiology.
Conclusions:
- Noninvasive MRI biomarkers are crucial for modern diagnostic radiology.
- MR biomarkers, especially in oncology, offer significant clinical advantages.
- Continued development of MRI techniques promises further diagnostic advancements.
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