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Related Concept Videos

Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Updated: Jan 8, 2026

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
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Ready for Routine: Homogeneous, High-Resolution, and Multicontrast Whole-Brain MRI at 7 Tesla in Short Scan Time With

Jennifer Faber, Daniel Paech, Eberhard Pracht

    Investigative Radiology
    |December 19, 2025
    PubMed
    Summary
    This summary is machine-generated.

    High-resolution 7T MRI is now clinically feasible, overcoming field inhomogeneities and long scan times with parallel transmit technology (pTx) and universal pulses (UPs). This advanced imaging offers improved homogeneity and quality for routine neuroradiology use.

    Keywords:
    7 Tesla7TCESTMPMMPRAGEinfratentorial structuresneuroradiologypTxultra-high field

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    Area of Science:

    • Neuroimaging
    • Magnetic Resonance Imaging (MRI)

    Background:

    • 7T MRI offers advanced imaging but faces challenges with field inhomogeneities and long scan times, limiting clinical adoption.
    • These limitations hinder whole-brain coverage and high-resolution imaging in routine practice.

    Purpose of the Study:

    • To develop and validate a calibration-free parallel transmit (pTx) technique using universal pulses (UPs) for homogenous multicontrast 7T MRI.
    • The goal is to achieve whole-brain coverage, high spatial resolution, and short scan times for clinical applications.

    Main Methods:

    • Custom MRI sequences utilizing pTx with UPs were developed and compared to conventional sequences in 10 healthy volunteers.
    • Anatomical and quantitative MRI protocols (MPM, CEST) were evaluated for image quality, homogeneity, and scan time.
    • The optimized protocol was demonstrated in 4 patients with various neurological diseases.

    Main Results:

    • Custom sequences with UPs significantly improved image homogeneity, quality, SNR, and CNR across the entire brain compared to conventional methods.
    • UPs enhanced the repeatability of quantitative MRI parameters.
    • Successful demonstration in patients with epilepsy, ataxia, angiopathy, and glioblastoma confirmed clinical applicability.

    Conclusions:

    • Homogeneous whole-brain 7T MRI with high resolution and quality is achievable within clinically feasible scan times.
    • The developed protocol is user-friendly and ready for clinical implementation, potentially increasing 7T MRI adoption in neuroradiology.