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Systemic Lithium Chloride Administration Improves Tooth Extraction Wound Healing in Estrogen-Deficient Rats
Poliana M Duarte1,2, Tamires S Miranda1, Letícia M Marins1
1Department of Periodontology, Dental Research Division, UNG - Universidade Guarulhos, Guarulhos, SP, Brazil.
Brazilian Dental Journal
|November 25, 2020
Summary
Lithium chloride (LiCl) supplementation improved bone healing in estrogen-deficient rats, particularly during early stages. Further research is needed to assess its clinical safety and optimal administration protocols.
Area of Science:
- Oral and Maxillofacial Surgery
- Bone Biology
- Pharmacology
Background:
- Estrogen deficiency, often due to ovariectomy, impairs bone healing.
- Lithium chloride (LiCl) is being investigated for potential therapeutic effects on bone metabolism.
Purpose of the Study:
- To evaluate the impact of lithium chloride (LiCl) on socket bone healing in an estrogen-deficient rat model.
Main Methods:
- Seventy-two rats underwent ovariectomy, with some receiving LiCl orally.
- First molars were extracted on day 21 post-ovariectomy.
- Bone healing, tartrate-resistant acid phosphatase (TRAP)-positive cells, and bone marker expression (OPG, RANKL, BSP, OPN, OCN) were assessed at 10, 20, and 30 days.
Main Results:
- LiCl administration improved bone healing at 10 days compared to ovariectomy alone.
- The ovariectomy group showed the poorest bone healing at 20 days.
- TRAP-positive cell counts were lowest in the LiCl group at 20 days.
- LiCl group exhibited enhanced expression of bone formation markers at 10 days.
Conclusions:
- Lithium chloride shows potential to enhance bone socket healing in estrogen-deficient conditions, especially in early phases.
- Preliminary findings suggest LiCl may modulate bone remodeling markers.
- Further investigation into LiCl's toxicity and optimal dosing is crucial for clinical application.
