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Asthma-chronic obstructive pulmonary disease overlap syndrome
Matthew F Mart1, Ray Stokes Peebles2
1Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Current Opinion in Immunology
|November 25, 2020
Summary
Overlap of asthma and chronic obstructive lung disease (ACO) is increasingly recognized but lacks clear diagnostic criteria. Research aims to define ACO
Area of Science:
- Pulmonology
- Respiratory Medicine
- Clinical Immunology
Background:
- Growing recognition of overlap between asthma and chronic obstructive lung disease (ACO).
- Lack of consistent diagnostic criteria for ACO presents a clinical challenge.
- ACO patients exhibit distinct clinical features and disease progression, indicating complex pathophysiology.
Purpose of the Study:
- To address the need for consistent diagnostic criteria for ACO.
- To explore the heterogeneous inflammatory pathophysiology underlying ACO.
- To review current and future treatment strategies for ACO.
Main Methods:
- Review of current literature on ACO diagnosis and treatment.
- Analysis of distinct clinical characteristics and trajectories in ACO patients.
- Discussion of emerging targeted biologic therapies and research directions.
Main Results:
- ACO represents a distinct clinical entity within obstructive lung disease.
- Current treatments focus on inhaled therapies, with growing interest in biologics.
- The inflammatory basis of ACO is multifactorial and not fully understood.
Conclusions:
- Further research is needed to elucidate ACO's inflammatory signatures.
- Development of consistent diagnostic criteria and biomarkers is crucial for ACO.
- Future management will likely involve targeted therapies based on individual inflammatory profiles.
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