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Peripheral Artery Disease in Diabetes Mellitus: Focus on Novel Treatment Options
Andrea Demarchi1, Alberto Somaschini2, Stefano Cornara3
1Cardiocentro Ticino, Lugano, Switzerland.
Abstract:
Diabetes mellitus (DM) and peripheral artery disease (PAD) are two clinical entities closely associated. They share many pathophysiological pathways such as inflammation, endothelial dysfunction, oxidative stress and pro-coagulative unbalance. Emerging data focusing on agents targeting these pathways may be promising. Moreover, due to the increased cardiovascular risk, there is a growing interest in cardiovascular and "pleiotropic" effects of novel glucose lowering drugs. This review summarizes the main clinical features of PAD in patients, the diagnostic process and current medical/interventional approaches, ranging from "classical treatment" to novel agents.
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