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Updated: Nov 28, 2025

Preparation of Binary and Ternary Deep Eutectic Systems
Published on: October 31, 2019
Deep eutectic solvents for solid pesticide dosage forms
Justin Phillips1, Walter W Focke2, Elizabeth L du Toit1
1Department of Chemical Engineering, Institute of Applied Materials, University of Pretoria, Hatfield, Private Bag X20, Pretoria, 0028, South Africa.
Abstract:
Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.
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