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Related Concept Videos

CRISPR01:59

CRISPR

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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CRISPR/Cas9 Genome Editing01:28

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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In-vitro Mutagenesis01:16

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To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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CRISPR and crRNAs02:53

CRISPR and crRNAs

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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Homologous Recombination02:31

Homologous Recombination

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The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
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Related Experiment Video

Updated: Nov 28, 2025

Author Spotlight: Streamlining Rice Breeding with CRISPR/Cas for Obtaining Optimal Phenotypic and Agronomic Traits
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[Current development of gene editing].

Debin Zhang1, Yao Luo1, Wenjin Chen1

  • 1College of Public Administration, Huazhong Agricultural University, Wuhan 430070, Hubei, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|November 27, 2020
PubMed
Summary
This summary is machine-generated.

Gene editing technology, including CRISPR/Cas9, offers significant opportunities for China, particularly in plant science applications. Strategic industrialization, public guidance, and safety standards are crucial for its advancement.

Keywords:
CRISPR/Cas9gene editingkey demandslogistic regressionpublic policy

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Area of Science:

  • Biotechnology
  • Agricultural Science
  • Genetics

Background:

  • CRISPR/Cas9 gene editing offers maneuverable, economical, and time-saving gene manipulation.
  • China has the potential to lead in gene editing research and industrialization, especially in plant applications.
  • Identifying key demands and applications is crucial for advancing gene editing in China.

Purpose of the Study:

  • To identify key demands and potential applications for gene editing technology in China.
  • To analyze the factors influencing the development and industrialization of gene editing in China.

Main Methods:

  • Questionnaire and statistical analysis were employed to gather data.
  • An ordered multi-classification logistic regression model was utilized for analysis.
  • Eight questionnaire questions across four categories were identified as significant independent variables.

Main Results:

  • Researchers identify plant science as the field with the greatest potential competitive advantages for gene editing.
  • Experts emphasize the need to focus on technology industrialization alongside basic research.
  • Synergy between research institutions, universities, and government is vital for development.

Conclusions:

  • Prioritizing industrialization and plant science applications is recommended for gene editing in China.
  • Effective public opinion guidance and a national safety standard system are urgently needed.
  • Risk management should focus on biological weapons, infectious diseases, and ecological impacts.