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Updated: Nov 28, 2025

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
[Malignant syphilis in a patient with HIV infection]
María Cecilia Garbarino1, Carla Trila2, Leandro Heffner1
1División Clínica Médica, Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina.
Abstract:
Malignant syphilis occurs frequently in patients infected with human immunodeficiency virus (HIV) and presents with cutaneous nodular lesions that tend to ulcerate. Non caseating granulomas are among the most conspicuous histopathological findings and require differential diagnosis with other infectious and non-infectious granulomatous conditions. The evolution of the disease is usually favourable with penicillin treatment. We present the case of an HIV-positive patient who meets diagnostic criteria for malignant syphilis and alert on this infrequent granulomatous entity.
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