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Prevalence of postenteritis cow's milk protein intolerance
Insights
This study investigated postinfectious cow's milk protein hypersensitivity (CMPH) in infants. Researchers found a low incidence of secondary CMPH following gastroenteritis, with only two cases confirmed.
Area of Science:
- Pediatric Gastroenterology
- Immunology
- Allergy Research
Background:
- Postinfectious cow's milk protein hypersensitivity (CMPH) can occur in infants after gastrointestinal infections.
- Understanding the incidence and characteristics of CMPH is crucial for infant health management.
Purpose of the Study:
- To determine the frequency of postinfectious cow's milk protein hypersensitivity (CMPH) in infants.
- To investigate the role of bacterial gastroenteritis in the development of CMPH.
Main Methods:
- A study involving 24 infants under 3 months old hospitalized for acute gastroenteritis.
- Infants received a protein hydrolysate formula for 6 weeks, followed by intestinal biopsy and a milk challenge.
- CMPH diagnosis was based on reduced mucosal disaccharidases post-challenge.
Main Results:
- Bacterial etiology was identified in 10 infants with gastroenteritis.
- Nineteen infants tolerated cow's milk without adverse reactions after 6 weeks on hypoallergenic formula.
- Two infants were diagnosed with secondary CMPH, both infected with Escherichia coli 0 111; one had primary CMPH, and one had extra-intestinal CMPH.
Conclusions:
- The incidence of secondary CMPH with gastrointestinal manifestations in this study was lower than previously reported.
- Early diagnosis and management of CMPH are essential for infants experiencing gastrointestinal distress post-infection.
Abstract:
The object of this study was to ascertain the frequency of postinfectious cow's milk protein hypersensitivity (CMPH). Twenty-four infants less than 3 months old were included in the study. Following hospitalization for acute gastroenteritis, the infants were given a protein hydrolysate formula for a period of 6 weeks, after which an intestinal biopsy was performed. Thereafter, a milk challenge was given. The existence of CMPH was defined as a postchallenge reduction of one or more of the mucosal disaccharidases below the normal levels for our laboratory. A bacterial etiology of the gastroenteritis was found in 10. Nineteen infants had no adverse reaction to cow's milk after 6 weeks on a hypoallergenic formula. Only two could be confidently diagnosed as having developed secondary CMPH; both had been infected by Escherichia coli 0 111. One infant had primary CMPH and one extra-intestinal CMPH. The incidence of secondary CMPH with gastrointestinal manifestations in this series was considerably less than described elsewhere.