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Prevalence of postenteritis cow's milk protein intolerance
Israel Journal of Medical Sciences
|November 1, 1987
Summary
This study investigated postinfectious cow's milk protein hypersensitivity (CMPH) in infants. Researchers found a low incidence of secondary CMPH following gastroenteritis, with only two cases confirmed.
Area of Science:
- Pediatric Gastroenterology
- Immunology
- Allergy Research
Background:
- Postinfectious cow's milk protein hypersensitivity (CMPH) can occur in infants after gastrointestinal infections.
- Understanding the incidence and characteristics of CMPH is crucial for infant health management.
Purpose of the Study:
- To determine the frequency of postinfectious cow's milk protein hypersensitivity (CMPH) in infants.
- To investigate the role of bacterial gastroenteritis in the development of CMPH.
Main Methods:
- A study involving 24 infants under 3 months old hospitalized for acute gastroenteritis.
- Infants received a protein hydrolysate formula for 6 weeks, followed by intestinal biopsy and a milk challenge.
- CMPH diagnosis was based on reduced mucosal disaccharidases post-challenge.
Main Results:
- Bacterial etiology was identified in 10 infants with gastroenteritis.
- Nineteen infants tolerated cow's milk without adverse reactions after 6 weeks on hypoallergenic formula.
- Two infants were diagnosed with secondary CMPH, both infected with Escherichia coli 0 111; one had primary CMPH, and one had extra-intestinal CMPH.
Conclusions:
- The incidence of secondary CMPH with gastrointestinal manifestations in this study was lower than previously reported.
- Early diagnosis and management of CMPH are essential for infants experiencing gastrointestinal distress post-infection.