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Exocrine pancreatic function in dogs with denervated pancreas
H Köhler1, R Nustede, M Barthel
1Department of General Surgery, University of Göttingen, Federal Republic of Germany.
Pancreas
|January 1, 1987
Summary
Vagus nerve denervation of the pancreas in dogs did not affect responses to secretin or caerulein. However, pancreatic denervation significantly reduced protein and bicarbonate secretion during the intestinal phase, particularly after food intake.
Area of Science:
- Gastroenterology
- Physiology
- Surgical Research
Background:
- The vagus nerve is known to influence exocrine pancreatic secretion.
- Understanding the role of extrinsic innervation is crucial for pancreatic function.
Purpose of the Study:
- To investigate the impact of complete extrinsic pancreatic denervation on exocrine secretion in dogs.
- To assess the sensitivity of the denervated pancreas to various stimuli.
Main Methods:
- Utilized an orthotopic autotransplantation model in dogs for pancreatic denervation.
- Administered secretin, caerulein, and intraintestinal L-tryptophan to assess pancreatic responses.
- Measured water, bicarbonate, and protein secretion.
Main Results:
- Denervation did not alter water and bicarbonate secretion in response to secretin.
- The denervated pancreas maintained sensitivity to caerulein.
- Protein secretion in response to intraintestinal L-tryptophan significantly decreased post-denervation.
- Bicarbonate and protein secretion after food intake were significantly reduced in denervated pancreases.
Conclusions:
- The denervated pancreas remains sensitive to exogenous secretin and caerulein.
- Extrinsic pancreatic denervation significantly impacts the intestinal phase of pancreatic secretion.
- Neural pathways beyond the vagus nerve are critical for mediating pancreatic secretion during digestion.