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CMR-derived ECVs vary with myocardial region and associate with the regional wall thickness

Mao-Yuan Su1,2, Kuei-Yuan Hou3,4,2, Ming-Hung Liu3

  • 1Department of Medical Imaging, National Taiwan University Hospital, Taipei, 10002, Taiwan, ROC.

Scientific Reports
|December 2, 2020
PubMed

Insights

Cardiac magnetic resonance extracellular volume fraction (ECV) measurements vary by myocardial region, influenced by wall thickness. Region of interest size has minimal impact on these important cardiovascular disease assessments.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Biomedical Engineering

Background:

  • Extracellular volume fraction (ECV) is a key biomarker in cardiovascular magnetic resonance (CMR) for assessing myocardial disease.
  • Standardization of ECV measurement is crucial for reliable clinical interpretation.
  • The influence of region of interest (ROI) placement and size on ECV quantification remains incompletely understood.

Purpose of the Study:

  • To investigate the impact of region of interest (ROI) position and size on extracellular volume fraction (ECV) measurements in the myocardium.
  • To determine the relationship between regional ECV and regional myocardial wall thickness.
  • To evaluate the diagnostic utility of regional ECV for differentiating cardiomyopathies.

Main Methods:

  • Retrospective analysis of CMR scans from patients with localized (n=203) or infiltrative (n=215) cardiomyopathies and 36 healthy controls.
  • ECV measurements were acquired from four myocardial regions: anterior, septal, posterior, and lateral walls.
  • ECV values were compared across different myocardial regions and correlated with regional wall thickness; five different ROI sizes were tested within each region.

Main Results:

  • Significant variations in ECV were observed among different myocardial regions, strongly correlating with regional wall thickness.
  • Regional ECV demonstrated comparable diagnostic power to whole-region ECV for detecting myocardial abnormalities, with the exception of the anterior region.
  • No significant differences in ECV measurements were found across the five tested ROI sizes.

Conclusions:

  • CMR-derived ECV values exhibit regional variability, which is significantly associated with regional myocardial wall thickness.
  • The size of the ROI used for ECV measurement has a limited effect on the overall quantification.
  • Understanding regional ECV variations is important for accurate interpretation in cardiomyopathies.

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