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Measurement of Tactile Allodynia in a Murine Model of Bacterial Prostatitis
Published on: January 16, 2013
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Lithogenic Potential of Ureaplasma in Chronic Prostatitis
Vittorio Magri1, Gianpaolo Perletti2,3, Konstantinos Stamatiou4
1Urology Secondary Care Clinic, ASST-Nord, Milan, Italy.
Urologia Internationalis
|December 2, 2020
Summary
Ureaplasma species (UPs) are linked to increased prostate calcifications, potentially contributing to chronic prostatitis. Their presence in prostatic fluids, not just the urethra, correlates with higher calcification rates and inflammation.
Area of Science:
- Urology
- Microbiology
- Pathogenesis Research
Background:
- The role of Ureaplasma species (UPs) in chronic prostatitis pathogenesis remains debated.
- UPs' lithogenic potential is a suspected risk factor for chronic prostatitis development.
Purpose of the Study:
- To investigate the association between Ureaplasma species identification and prostate calcifications.
- To explore the correlation between UPs location (urethral vs. prostatic) and clinical markers in prostatitis patients.
Main Methods:
- Retrospective analysis of 143 patients with UPs and control groups (chronic bacterial prostatitis, Chlamydia trachomatis, chronic pelvic pain syndrome).
- Microbiological evaluation for UPs and Mycoplasma hominis using a semiquantitative assay.
- Clinical, microscopic, and transrectal prostate ultrasound assessments were performed.
Main Results:
- Patients with UPs showed significantly higher rates of prostate calcifications (64%) compared to controls.
- Calcifications were more prevalent in prostatic UPs (71%) and associated UPs (73%) than urethral UPs (34%).
- Higher white blood cell counts in sperm were observed in patients with prostatic and associated UPs.
Conclusions:
- Ureaplasma species identification in urogenital fluids correlates with increased prostate calcifications.
- UPs' ability to promote calcification may contribute to chronic prostatitis.
- Prostatic UPs are associated with higher calcification rates and inflammation, suggesting a causative role in pathogenesis.
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