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Related Experiment Video

Updated: Nov 27, 2025

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Ginsenoside Rg1 promotes lymphatic drainage and improves chronic inflammatory arthritis.

Tong Hou1,2, Yang Liu2, Xiaoyun Wang2

  • 1Central Hospital of Jing'an District, Fudan University, Shanghai, China.

Journal of Musculoskeletal & Neuronal Interactions
|December 3, 2020
PubMed
Summary

Ginsenoside Rg1 enhances lymphatic drainage and reduces joint inflammation in mice with inflammatory arthritis. This natural compound shows potential as a therapeutic agent for treating joint diseases.

Keywords:
Ginsenoside Rg1Inflammatory ArthritisLymphatic DrainageTNF-α

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Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • The lymphatic system is crucial in the pathogenesis of joint diseases.
  • Dysfunctional lymphatic drainage can exacerbate joint inflammation and damage.

Purpose of the Study:

  • To investigate the therapeutic effects of ginsenoside Rg1 on lymphatic function and joint inflammation.
  • To evaluate ginsenoside Rg1's impact on inflammatory markers and joint pathology in a mouse model.

Main Methods:

  • Utilized tumor necrosis factor alpha (TNF-α) transgenic mice (TNF-Tg) as an arthritis model.
  • Administered ginsenoside Rg1 for 12 weeks, assessing lymphatic drainage via near-infrared indocyanine green (NIR-ICG) imaging.
  • Analyzed joint pathology, inflammatory markers (IL-6, TNF-α), and lymphatic vessel structure.

Main Results:

  • Ginsenoside Rg1 significantly improved lymphatic drainage in TNF-Tg mice.
  • Reduced synovial inflammation, bone erosion, and serum levels of IL-6 and TNF-α.
  • Increased smooth muscle coverage on lymphatic vessels without causing liver or kidney damage.

Conclusions:

  • Ginsenoside Rg1 effectively improves lymphatic drainage and mitigates joint inflammation in a mouse model of inflammatory arthritis.
  • Ginsenoside Rg1 demonstrates potential as a novel therapeutic candidate for inflammatory arthritis.