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Related Experiment Video

Updated: Sep 30, 2025

Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase G6PI-Induced RA Mice
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Notoginsenoside R1 (NG-R1) Promoted Lymphatic Drainage Function to Ameliorating Rheumatoid Arthritis in TNF-Tg Mice

Danli Jiao1,2,3,4, Yang Liu1,3,4, Tong Hou1,3,4

  • 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Pharmacology
|March 14, 2022
PubMed
Summary

NG-R1, derived from Sanchi, enhances lymphatic drainage to reduce inflammation and bone destruction in rheumatoid arthritis (RA). This compound suppresses the NF-κB pathway, offering a potential therapeutic approach for RA.

Keywords:
NF-κB signaling pathwayTNF-Tg miceinflammationlymphatic drainage functionnotoginsenoside R1rheumatoid arthritis

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Area of Science:

  • Immunology
  • Rheumatology
  • Pharmacology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by synovial inflammation.
  • The lymphatic system plays a crucial role in RA development and progression; improved lymph drainage can reduce joint inflammation.

Purpose of the Study:

  • To investigate the therapeutic potential of NG-R1, an active component of Sanchi, in ameliorating rheumatoid arthritis.
  • To elucidate the molecular mechanisms by which NG-R1 improves lymphatic function and reduces inflammation in RA.

Main Methods:

  • Histopathological staining of ankle sections in TNF-Tg mice to assess inflammation and bone destruction.
  • Near-infrared-indocyanine green (NIR-ICG) lymphatic imaging to evaluate lymphatic drainage function.
  • In-vitro studies on lymphatic endothelial cells (LECs) stimulated with TNF-α to analyze molecular pathways.

Main Results:

  • NG-R1 significantly decreased inflammation and bone destruction in the ankle joints of TNF-Tg mice.
  • NG-R1 administration demonstrably improved lymphatic drainage function, as evidenced by NIR-ICG imaging.
  • NG-R1 inhibited inflammatory cytokine production in LECs by suppressing the NF-κB signaling pathway, including IKKα/β and p65 phosphorylation and nuclear translocation.

Conclusions:

  • NG-R1 effectively promotes lymphatic drainage and attenuates synovial inflammation in a mouse model of RA.
  • The therapeutic effects of NG-R1 in RA are mediated through the suppression of the NF-κB signaling pathway.
  • NG-R1 represents a promising therapeutic agent for rheumatoid arthritis by targeting lymphatic dysfunction and inflammation.