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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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Choroidal vessel density in unilateral hyperopic amblyopia using en-face optical coherence tomography.
Syunsuke Araki1,2, Atsushi Miki3,4,5,6, Katsutoshi Goto1
1Department of Ophthalmology, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.
BMC Ophthalmology
|December 3, 2020
Summary
Choroidal vascular density (CVD) in Haller's layer did not differ between amblyopic, fellow, and normal eyes in children with unilateral hyperopic amblyopia. These findings suggest local CVD is unaffected in amblyopic eyes.
Area of Science:
- Ophthalmology
- Optometry
- Medical Imaging
Background:
- Choroidal thickening is observed in amblyopic eyes with hyperopic anisometropia.
- Previous studies suggest structural changes in the choroid of amblyopic eyes.
Purpose of the Study:
- To investigate choroidal vascular density (CVD) in Haller's layer in children with unilateral hyperopic amblyopia.
- To compare CVD between amblyopic, fellow, and normal control eyes.
Main Methods:
- Quantified CVD in Haller's layer using 3D swept-source OCT en-face images.
- Analyzed a 3x3 mm macular area after magnification correction.
- Included 44 patients with unilateral amblyopia and 29 normal controls.
Main Results:
- Mean CVD was similar across amblyopic (59.11%), fellow (59.23%), and control eyes (59.29%).
- CVD showed a positive correlation with subfoveal choroidal thickness (SFCT).
- No significant differences in CVD were found among groups after adjusting for SFCT.
Conclusions:
- Choroidal vascular density in Haller's layer is not significantly different in unilateral hyperopic amblyopic eyes.
- CVD was unrelated to best-corrected visual acuity (BCVA).
- Local CVD appears unaffected in this cohort.
