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THE MAIN CAUSES OF THE COMPLICATED COURSE OF COVID-19 IN PATIENTS WITH DIABETES MELLITUS AND TREATMENT (REVIEW)
O Halushko1, O Loskutov1, I Kuchynska1
1Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine.
Insights
Diabetic patients face severe Coronavirus disease 2019 (COVID-19) due to diabetes features and drug interactions. Managing COVID-19 in diabetics requires normalizing blood sugar and a multidisciplinary approach.
Area of Science:
- Endocrinology
- Infectious Diseases
- Public Health
Background:
- Diabetes Mellitus (DM) and advanced age are key risk factors for severe Coronavirus disease 2019 (COVID-19).
- Understanding COVID-19 complications in diabetic populations is critical for effective management.
- Existing research highlights the interplay between chronic conditions and viral infections.
Purpose of the Study:
- To identify the primary causes of complicated COVID-19 courses specifically in patients with diabetes.
- To analyze the pathogenetic mechanisms underlying COVID-19 complications in individuals with DM.
- To inform evidence-based treatment strategies for this vulnerable group.
Main Methods:
- A comprehensive literature search was conducted using PubMed and Google Scholar.
- Keywords included: COVID-19, diabetes, hyperglycemia, carbohydrate metabolism disorders, and complications.
- A systematic review of scientific literature was performed to synthesize findings.
Main Results:
- Features of DM and its interaction with COVID-19 significantly worsen disease severity.
- Specific medication classes used for both conditions can exacerbate complications.
- Organizational shortcomings in patient care and treatment planning contribute to adverse outcomes.
- Normalization of blood glucose and carbohydrate metabolism is paramount for managing these patients.
Conclusions:
- Effective COVID-19 management in diabetic patients necessitates addressing DM-specific factors and drug influences.
- A multidisciplinary team approach involving specialists in emergency medicine, endocrinology, infectious diseases, respiratory support, nutrition, and rehabilitation is essential.
- Prioritizing blood sugar control is the most crucial factor in improving outcomes for diabetic patients with COVID-19.
Abstract:
Among the main risk factors for the development of a severe course of Coronavirus disease 2019 (COVID-19) are old age, arterial hypertension, diabetes mellitus (DM), chronic obstructive pulmonary diseases, cardiovascular and cerebrovascular diseases. The aim of this study was determinating the main causes of complicated COVID-19 course in diabetic patients. Publications were searched using PubMed and Google Scholar for keywords: COVID-19, diabetes, hyperglycemia, carbohydrate metabolism disorders, and complications. The review of scientific literature considers the main causes and pathogenetic mechanisms of COVID-19 complications development in patients with DM. Groups of factors that worsen the disease course were identified. We also proved that modern treatment of COVID-19 in diabetic patients should consider all risk factors and include a multidisciplinary team approach with specialists in emergency medicine, endocrinology, infectious diseases, respiratory support, nutrition and rehabilitation. The main reasons that worsen the course of COVID-19 in patients with DM are features of DM and mutual influence of DM and COVID-19; the influence of separate medicines groups used in the treatment of both diseases; shortcomings in the organization of patients' treatment and care. The main factor that is crucial in the management of these patients is the normalization of blood sugar level and carbohydrates metabolism achieved by all possible means.
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