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Published on: November 16, 2016
[CHARACTERISTICS OF LEVOFLOXACIN AND ITS CLINICAL APPLICATION (REVIEW)]
E Shtaniuk1, T Kovalenko1, L Krasnikova1
1Kharkiv National Medical University, Ukraine.
Abstract:
We analyzed of the effectiveness of levofloxacin in various diseases, the sensitivity of microorganisms to it and side effects. LF does not show carcinogenic, mutagenic and teratogenic activity. It is used effectively in the treatment of infections of the respiratory and genitourinary tract, skin and soft tissues, for the prevention of complications in surgical practice, as well as infections of many other localizations. Levofloxacin has a wide spectrum of action, including most gram-positive and gram-negative pathogens, including intracellularly located, unlike other fluoroquinolones, highly active against gram-positive cocci, including pneumococci which are resistant to penicillin, erythromycin. In addition, levofloxacin is more active against atypical pathogens. Doctors should clearly justife the appointment of LF in an adequate dose in each case, in order to avoid or reduce the occurrence of resistance of pathogens to it.
Insights
Levofloxacin effectively treats various infections and shows no carcinogenic effects. Judicious use is crucial to prevent pathogen resistance to this broad-spectrum antibiotic.
Area of Science:
- Pharmacology
- Infectious Diseases
- Microbiology
Background:
- Levofloxacin (LF) is a fluoroquinolone antibiotic with broad-spectrum activity.
- Understanding its efficacy, safety, and antimicrobial spectrum is vital for clinical practice.
Purpose of the Study:
- To analyze the effectiveness of levofloxacin across various infections.
- To evaluate microbial sensitivity to levofloxacin.
- To assess the safety profile, including side effects and genotoxicity.
Main Methods:
- Review of existing literature on levofloxacin's clinical applications.
- Analysis of antimicrobial susceptibility data.
- Evaluation of safety studies regarding carcinogenic, mutagenic, and teratogenic potential.
Main Results:
- Levofloxacin demonstrates high efficacy in treating respiratory, genitourinary, and skin infections.
- It exhibits broad-spectrum activity against Gram-positive and Gram-negative pathogens, including intracellular and penicillin-resistant strains.
- Levofloxacin shows no carcinogenic, mutagenic, or teratogenic activity.
Conclusions:
- Levofloxacin is a safe and effective antibiotic for numerous infections.
- Its activity against resistant and atypical pathogens makes it a valuable therapeutic option.
- Appropriate dosing and justified prescription are essential to mitigate antimicrobial resistance.
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