PAKC: A novel panel of HLA class I antigen presentation machinery knockout cells from the same genetic origin

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Antonius A de Waard1,2, Tamara Verkerk1,2, Marlieke L M Jongsma1,2,3

  • 1Department of Immunopathology, Sanquin Research, Amsterdam, The Netherlands.

European Journal of Immunology
|December 4, 2020
PubMed

A single model system for integrative studies on multiple facets of antigen presentation is lacking. PAKC is a novel panel of ten cell lines knocked out for individual components of the HLA class I antigen presentation pathway. PAKC will accelerate HLA-I research in the fields of oncology, infectiology, and autoimmunity.

Keywords:
APMCRISPR/Cas9HLA class IMHCantigen presentation

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