High Expression of ACKR4 in Thymic Epithelial Progenitors of Adult Mice
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Updated: Nov 1, 2026

Preparation of Single-Cell Suspension of Mouse Thymic Epithelial Cells and Staining of Intracellular Molecules for Flow Cytometric Analysis
Published on: July 26, 2024
Elin Hub1, Chikako Odaka1, Stefan Russo1
1Centre for Microvascular Research, The William Harvey Research Institute, Queen Mary University of London, London, UK.
Abstract:
High ACKR4-expressing cells located in the subcapsular zone and around pericytes at the corticomedullary junction express thymic epithelial cell (TEC) progenitor markers. During cortical TEC regeneration in adult mice, ACKR4 expression is upregulated in cells expressing the transcription factors p63 and Foxn1. Our findings suggest that ACKR4 is preferentially expressed in thymic epithelial progenitors in adult mice.
