Multi-speckle diffuse correlation spectroscopy to measure cerebral blood flow

We present a multi-speckle diffuse correlation spectroscopy (DCS) system for measuring cerebral blood flow in the healthy adult human brain. In contrast to the need for a high frame rate camera to measure the multi-speckle intensity auto-correlation, we employ a low frame rate camera to measure the auto-correlation using the recently introduced multi-step volterra integral method (MVIM). The results are validated by comparison against the blood flow measured using standard DCS system.