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Association between serum SCUBE1 levels and thrombus burden in patients with ST-segment elevation myocardial

Arafat Yıldırım1, Mehmet Kücükosmanoglu1, Nermin Yildiz Koyunsever1

  • 1Department of Cardiology, University of Health Sciences - Adana Health Practice and Research Center, Adana, Turkey.

Acta Cardiologica
|December 7, 2020
PubMed

Insights

Signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) is a novel biomarker for platelet activation. Elevated SCUBE1 levels independently predict high thrombus burden in ST-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Thrombosis Research

Background:

  • Signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) is expressed by activated platelets.
  • SCUBE1 is a potential biomarker for platelet activation and adhesion.

Purpose of the Study:

  • To investigate the association between SCUBE1 levels and thrombus burden.
  • To evaluate SCUBE1 as a predictor of high thrombus burden in STEMI patients undergoing PPCI.

Main Methods:

  • Prospective study of 88 STEMI patients undergoing PPCI.
  • Serum SCUBE1 levels measured before PPCI and antiplatelet therapy.
  • Thrombus burden assessed using TIMI thrombus grades.

Main Results:

  • Higher SCUBE1 levels were observed in patients with high thrombus burden (p < .05).
  • SCUBE1 level >65.63 ng/dL predicted high thrombus burden with 91.9% sensitivity and 76.6% specificity (AUC: 0.9256).
  • SCUBE1 was an independent predictor of high thrombus burden (HR: 1.133, p = .004).

Conclusions:

  • SCUBE1 is a novel platelet-endothelial adhesion molecule and marker of platelet activation.
  • SCUBE1 is an independent predictor of high thrombus burden in STEMI patients.
Abstract

Keywords:
ST elevation myocardial infarctionSignal peptide-CUB-EGF domain-containing protein-1thrombus burden

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