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Related Concept Videos

Inflammation01:38

Inflammation

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Overview
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Caspases01:24

Caspases

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Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside...
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Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

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The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
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Related Experiment Video

Updated: Nov 26, 2025

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
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COVID-19 stokes inflammasomes.

Clare Bryant1

  • 1Departments of Medicine and Veterinary Medicine, The University of Cambridge, Cambridge, UK.

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This summary is machine-generated.

Severe sepsis in SARS-CoV-2 infections poses treatment challenges. Inflammasome activation in COVID-19 may offer new therapeutic targets for managing sepsis syndromes.

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Area of Science:

  • Immunology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Severe sepsis management remains challenging, particularly in patients with SARS-CoV-2 infections.
  • Systemic inflammatory conditions require effective therapeutic strategies.
  • The role of inflammasome activation in COVID-19 pathogenesis is under investigation.

Purpose of the Study:

  • To discuss the role of inflammasome activation in the severity of COVID-19.
  • To explore potential therapeutic avenues for sepsis syndromes associated with COVID-19.

Main Methods:

  • Review and discussion of existing literature on inflammasome pathways and COVID-19.
  • Analysis of the link between inflammasome activation and disease severity in SARS-CoV-2 infections.

Main Results:

  • Inflammasome activation is implicated in the heightened inflammatory response observed in severe COVID-19.
  • Dysregulated inflammasome activity contributes to the pathogenesis of sepsis syndromes in COVID-19 patients.

Conclusions:

  • Targeting inflammasome activation presents a promising strategy for managing severe COVID-19 and associated sepsis syndromes.
  • Further research into inflammasome inhibitors could lead to novel treatments for critical illness in SARS-CoV-2 infections.