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Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Multi-species Conserved Sequences02:51

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Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
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Sanger Sequencing01:57

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DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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Synteny and Evolution02:31

Synteny and Evolution

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John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
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What is Evolutionary History?02:35

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Scientists record evolutionary history by analyzing fossil, morphological, and genetic data. The fossil record documents the history of life on Earth and provides evidence for evolution. However, both fossil and living organisms offer evidence that outlines Earth’s evolutionary history.
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Related Experiment Video

Updated: Nov 26, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

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Evolutionary Sequence Analysis and Visualization with Wasabi.

Andres Veidenberg1, Ari Löytynoja2

  • 1Institute of Biotechnology, University of Helsinki, Helsinki, Finland. andres.veidenberg@helsinki.fi.

Methods in Molecular Biology (Clifton, N.J.)
|December 8, 2020
PubMed
Summary
This summary is machine-generated.

Wasabi is a web-based tool for evolutionary sequence analysis and visualization. It offers reproducible research through workflow histories and easy data sharing for collaboration.

Keywords:
Data visualizationEvolutionary sequence analysisReproducible researchWeb application

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Evolutionary Biology

Background:

  • Evolutionary sequence analysis requires integrated visualization and phylogenetic context.
  • Existing tools may lack interactivity, extensibility, or support for reproducible research.

Purpose of the Study:

  • To introduce Wasabi, an open-source, web-based graphical environment for evolutionary sequence analysis.
  • To detail its features for interactive analysis, visualization, and collaborative research.

Main Methods:

  • Developed as a web-based graphical environment with an interactive user interface.
  • Incorporates a plugin system for extensibility with custom tools and pipelines.
  • Stores analysis steps as workflow histories for reproducibility.

Main Results:

  • Wasabi provides convenient access to external data and computational tools.
  • Facilitates reproducible, collaborative research through shared analyses and web links.
  • Supports branched analysis pipelines, data visualization, and publishing of results.

Conclusions:

  • Wasabi offers a versatile and user-friendly platform for evolutionary sequence analysis.
  • Its web-based design ensures cross-platform compatibility and straightforward integration with other web services.
  • The tool promotes reproducible, collaborative, and easily disseminable research in evolutionary biology.