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Indirect calorimetry.

E Jéquier, J P Felber

Bailliere'S Clinical Endocrinology and Metabolism

|November 1, 1987

Summary

This summary is machine-generated.

Indirect calorimetry measures energy expenditure and substrate use. Impaired glucose storage is a key issue in type II diabetes, affecting glucose utilization.

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Area of Science:

Metabolic Physiology
Human Metabolism

Background:

Indirect calorimetry non-invasively measures human energy expenditure and substrate utilization.
Understanding metabolic processes like gluconeogenesis, ketogenesis, and lipogenesis is crucial for interpreting results.

Purpose of the Study:

To investigate carbohydrate and lipid metabolism in lean, obese, and diabetic individuals using indirect calorimetry.
To assess the impact of insulin on glucose metabolism and storage.

Main Methods:

Utilized indirect calorimetry with a ventilated hood system for continuous metabolic rate and respiratory quotient measurements.
Employed euglycaemic insulin clamp technique and oral glucose loads to study insulin's effects.
Manipulated plasma free fatty acid levels to observe effects on glucose metabolism.

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Main Results:

Insulin primarily stimulates glucose storage in carbohydrate metabolism.
Elevated free fatty acids impaired both glucose oxidation and storage in lean subjects.
Glucose storage was significantly impaired in obese and diabetic patients, particularly under insulin clamp conditions.

Conclusions:

Impaired glucose storage is a primary defect in glucose utilization for individuals with type II diabetes.
This defect is exacerbated by elevated lipid oxidation and is evident even after oral glucose challenges.