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Updated: Nov 25, 2025

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Synthesis of Cyclic Amidines by Iridium-Catalyzed Deoxygenative Reduction of Lactams and Tandem Reaction with
Youliang He1, Xiaoming Wang1,2
1State Key Laboratory of Oganometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences (CAS), 345 Lingling Road, Shanghai 200032, P. R. China.
Abstract:
An efficient and convenient synthesis of various cyclic amidines has been achieved via iridium-catalyzed deoxygenative reduction of lactams with a silane followed by a one-pot cycloaddition reaction with sulfonyl azides. Using the novel tandem procedure, a large array of cyclic amidines bearing various sized rings were synthesized in good yields from readily available lactams. This methodology has been successfully utilized in the late stage diversification of complex architectures bearing a lactam moiety.
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