Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

96
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
96
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

131
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
131
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

2.2K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
2.2K
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

4.9K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
4.9K
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

79
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
79
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

4.1K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International survey in four European countries on diagnostic reference levels based on clinical indications in computed tomography.

Insights into imaging·2026
Same author

Correction: Requirements for Physico-Technical Quality Assurance in the Framework of Early Detection of Lung Cancer.

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin·2026
Same author

Requirements for Physico-Technical Quality Assurance in the Framework of Early Detection of Lung Cancer.

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin·2025
Same author

CBCT-based online adaptive radiotherapy of the bladder - geometrical and dosimetrical considerations compared to conventional IGRT.

Radiation oncology (London, England)·2025
Same author

International survey on diagnostic reference levels based on clinical indications in plain radiography.

European radiology·2024
Same author

Pediatric computed tomography doses in Germany from 2016 to 2018 based on large-scale data collection.

European journal of radiology·2023

Related Experiment Video

Updated: Nov 25, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.2K

[Procurement strategy for a dose management system].

Georg Stamm1, Hans-Werner Rübel2

  • 1Institut für Diagnostische und Interventionelle Radiologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland. georg.stamm@med.uni-goettingen.de.

Der Radiologe
|December 17, 2020
PubMed
Summary
This summary is machine-generated.

Procuring a dose management system for university hospitals involves a structured process from Europe-wide proposals to final selection. Engaging external consultants and user-led evaluations are crucial for successful system implementation and total cost of ownership (TCO) calculation.

Keywords:
Dose management systemFunctionalityMinimum requirementsRating schemeUse cases

More Related Videos

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.7K
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.4K

Related Experiment Videos

Last Updated: Nov 25, 2025

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models
04:59

Author Spotlight: Developing a Disposable Dosator for Preclinical Testing of Dry Powder Inhalers in Small Animal Models

Published on: August 18, 2023

1.2K
Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

15.7K
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

10.4K

Area of Science:

  • Healthcare Technology Procurement
  • Medical Physics
  • Radiology Informatics

Background:

  • University hospitals require robust dose management systems for radiation safety and compliance.
  • Procurement of complex medical systems necessitates a systematic approach to ensure optimal functionality and cost-effectiveness.

Purpose of the Study:

  • To outline the key steps and considerations for procuring a dose management system in a university hospital setting.
  • To emphasize the importance of external consultants and user involvement in the procurement process.

Main Methods:

  • Initiating a Europe-wide request for proposals (RFP) for dose management systems.
  • Conducting supplier product presentations and evaluating system functionalities through use cases.
  • Involving qualified end-users (medical physics experts, radiologists, technicians, quality management) in the evaluation and decision-making process.

Main Results:

  • External consultants are recommended for system specification development and total cost of ownership (TCO) calculation.
  • Use cases proved essential for assessing system functionality, leading to adjustments in specifications and minimum requirements.
  • A multidisciplinary user team is vital for informed evaluation and final product selection.

Conclusions:

  • A structured, user-centric procurement process, supported by expert consultation, is essential for selecting an effective dose management system.
  • Thorough evaluation of system specifications, TCO, and vendor capabilities ensures alignment with hospital needs and regulatory requirements.