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Related Concept Videos

Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Zygotic Development And Stem Cell Formation01:10

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Related Experiment Video

Updated: Nov 25, 2025

Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics
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Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics

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Modeling human embryo development with embryonic and extra-embryonic stem cells.

Bailey A T Weatherbee1, Tongtong Cui2, Magdalena Zernicka-Goetz3

  • 1Mouse and Human Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, CB2 3EG, UK.

Developmental Biology
|December 17, 2020
PubMed
Summary
This summary is machine-generated.

Investigating early human development is crucial due to pregnancy loss risks. Stem cell models offer insights into human embryogenesis, aiding research into critical developmental stages.

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Reproductive Medicine

Background:

  • Early human post-implantation development is complex, with failures leading to pregnancy loss.
  • Ethical and technical challenges limit direct study of natural human embryos.
  • Understanding these early stages is vital for reproductive health.

Purpose of the Study:

  • To review stem cell-derived models for studying human embryogenesis.
  • To highlight the utility of current stem cell models.
  • To propose advanced models for deeper mechanistic insights.

Main Methods:

  • Overview of existing stem cell types representing early human lineages (epiblast, hypoblast, trophoblast).
  • Review of human embryonic stem cells for modeling epiblast morphogenesis and differentiation.
  • Proposal for 3D embryo models combining embryonic and extra-embryonic stem cells.

Main Results:

  • Human embryonic stem cells, hypoblast-like stem cells, and trophoblast stem cells represent key early lineages.
  • Human embryonic stem cells can model epiblast morphogenesis and differentiation.
  • Combined stem cell models offer potential for studying crucial cell interactions.

Conclusions:

  • Stem cell-derived models are invaluable, though imperfect, tools for studying human embryogenesis.
  • Advanced 3D embryo models integrating multiple stem cell types can elucidate essential cell-cell interactions.
  • Further development of these models is key to understanding and potentially preventing early pregnancy loss.