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Lifetime Allergy Symptoms in IgG4-Related Disease: A Case-Control Study
Samantha Sanders1, Xiaoqing Fu2, Yuqing Zhang3
1Harvard Medical School, Boston, Massachusetts.
Arthritis Care & Research
|December 20, 2020
Summary
Lifetime allergy symptoms are common in IgG4-related disease (IgG4-RD). However, allergies are not more prevalent in IgG4-RD patients than in controls, suggesting they aren't uniquely linked to the disease.
Area of Science:
- Immunology
- Rheumatology
- Allergy and Clinical Immunology
Background:
- The etiology of IgG4-related disease (IgG4-RD) remains unknown.
- The role of allergic conditions in IgG4-RD pathogenesis is debated.
Purpose of the Study:
- To investigate the prevalence of lifetime allergy symptoms in IgG4-RD patients.
- To determine the association between allergy symptoms and IgG4-RD features.
Main Methods:
- Identified IgG4-RD patients and matched controls without autoimmune conditions.
- Assessed allergy symptoms via questionnaire.
- Used conditional logistic regression to compare allergy prevalence between groups.
Main Results:
- 71% of IgG4-RD patients reported lifetime allergy symptoms (aeroallergens, skin, food).
- IgG4-RD patients with allergies showed increased head/neck involvement and eosinophilia.
- Overall allergy prevalence was similar between IgG4-RD cases and controls.
Conclusions:
- Lifetime allergy symptoms are frequent in IgG4-RD but not uniquely associated with the disease.
- Allergies do not appear to be uniquely linked to the pathogenesis or presentation of IgG4-RD.
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