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Related Concept Videos

Drug Therapy01:28

Drug Therapy

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
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Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Psychosis: Goals of Pharmacotherapy01:26

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Antipsychotic Drugs: Therapeutic Uses and Side Effects01:21

Antipsychotic Drugs: Therapeutic Uses and Side Effects

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Antipsychotic drugs primarily block dopamine and serotonin receptors and cholinergic, adrenergic, and histaminergic receptors, thereby reducing hallucinations and delusions in conditions like schizophrenia. However, they can trigger unwanted extrapyramidal effects such as dystonias, Parkinson-like symptoms, and tardive dyskinesia.
Despite these side effects, antipsychotics are used therapeutically for various purposes, including managing schizophrenia, preventing nausea and vomiting, curbing...
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Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

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Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
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Drug Dosing: Geriatric Patients01:15

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
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Antipsychotic Polypharmacy.

Adriana Foster1, Jordanne King1

  • 1Department of Psychiatry and Behavioral Health, Herbert Wertheim College of Medicine, Florida International University, Miami (Foster, King); Citrus Health Network Inc., Hialeah, Florida (Foster, King).

Focus (American Psychiatric Publishing)
|December 21, 2020
PubMed
Summary
This summary is machine-generated.

Antipsychotic polypharmacy is sometimes used for schizophrenia when other treatments fail, but evidence for its benefits is limited. Alternative augmentation strategies may offer better outcomes for patients.

Keywords:
AntipsychoticsSchizophrenia

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Medicine

Background:

  • Schizophrenia treatment guidelines do not fully address complex clinical scenarios.
  • Antipsychotic polypharmacy is often employed when clozapine access is limited or monotherapy is ineffective.

Purpose of the Study:

  • To examine the role of antipsychotic polypharmacy in current schizophrenia treatment.
  • To review the prevalence, clinical contexts, and pharmacological basis of antipsychotic polypharmacy.

Main Methods:

  • Literature review of antipsychotic polypharmacy prevalence and risks.
  • Analysis of clinical situations necessitating polypharmacy.
  • Exploration of alternative antipsychotic augmentation strategies.

Main Results:

  • Antipsychotic polypharmacy is encountered in complex schizophrenia cases.
  • Limited evidence supports the benefits of antipsychotic polypharmacy.
  • Common risks associated with antipsychotic polypharmacy are reviewed.

Conclusions:

  • Antipsychotic polypharmacy presents challenges in schizophrenia management.
  • Further research into alternative augmentation strategies is warranted.
  • Addressing clinical and social barriers to clozapine is crucial.