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Updated: Nov 24, 2025

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
Published on: August 11, 2019
[Progress in the encoding characteristics and mechanisms of hippocampal neural assemble sequences in spatial memory]
Yi-Yuan Zhang1,2, Nan Zhu1,2, Jia-Jia Yang1,2
1Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072, China.
Abstract:
The formation, consolidation and retrieval of spatial memory depend on sequential firing patterns of place cells assembling in the hippocampus. Theta sequences of place cells during behavior play a role in acquisition of spatial memory, trajectory prediction and decision making. In awake rest and slow wave sleep, place cell sequences occur during the sharp wave-ripples (SWRs), called "replay", which is crucial for memory consolidation and retrieval. In this review, we summarize the functional significances of theta sequences and SWRs replay sequences and the mechanism of these sequences. We also discuss the relationship between theta and replay sequences with the formation of spatial memory. We propose the research direction in this field in future and aim to provide new ideas for related researches.
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