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Updated: Nov 24, 2025

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
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Published on: March 20, 2014

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Is the reaction sequence in phosphine-catalyzed [8+2] cycloaddition controlled by electrophilicity?

Wen-Xuan Lin1, Zhuolin Pei1, Cunxi Gong1

  • 1Green Catalysis Center, and College of Chemistry, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan 450001, P. R. China. jssong@zzu.edu.cn lishijunzong@zzu.edu.cn.

Chemical Communications (Cambridge, England)
|December 22, 2020
PubMed
Summary

This study reveals that electrophilicity alone cannot predict reaction outcomes in phosphine-catalyzed [8+2] cycloadditions. Density Functional Theory (DFT) calculations highlight the complexity beyond simple electrophilicity for these important organic reactions.

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