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Oxo-Titanium(IV) Complex/Polymer Composites-Synthesis, Spectroscopic Characterization and Antimicrobial Activity Test
Piotr Piszczek1, Barbara Kubiak1, Patrycja Golińska2
1Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Gagarina 7, 87-100 Toruń, Poland.
International Journal of Molecular Sciences
|December 23, 2020
Summary
New titanium(IV) oxo-complexes (TOCs) dispersed in poly(methyl methacrylate) (PMMA) composites exhibit potent microbiocidal activity. These materials demonstrate effectiveness against bacteria and yeast, offering potential solutions for microbial contamination control.
Area of Science:
- Materials Science
- Inorganic Chemistry
- Microbiology
Background:
- Rising antimicrobial resistance necessitates novel antimicrobial agents.
- Titanium oxo-complexes (TOCs) are explored for their potential antimicrobial properties.
- Poly(methyl methacrylate) (PMMA) serves as a matrix for dispersing antimicrobial agents.
Purpose of the Study:
- To synthesize and characterize tri- and tetranuclear oxo-titanium(IV) complexes (TOCs).
- To evaluate the antimicrobial activity of PMMA composites containing TOCs.
- To assess the potential applications of these composites in controlling microbial contamination.
Main Methods:
- Synthesis of TOCs via reaction of Ti(OR)4 with HO2CR' ligands.
- Characterization of TOCs using IR spectroscopy, Raman spectroscopy, and mass spectrometry.
- Preparation of PMMA + TOCs composites and testing their microbiocidal activity against bacteria and yeast strains.
Main Results:
- All synthesized PMMA + TOCs composites exhibited biocidal activity against Gram-positive and Gram-negative bacteria.
- Composites with {Ti4O2} and {Ti3O} cores showed high activity against Candida albicans.
- The structural integrity and antimicrobial efficacy of the composites were confirmed.
Conclusions:
- The developed PMMA + TOCs composites possess significant microbiocidal properties.
- These composites show promise for applications in eliminating microbial contamination in diverse settings.
- Further research can explore their use in medical devices, coatings, and other relevant fields.
