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Charles Darwin proposed that facial expressions are an evolutionary adaptation for communication. He argued that these expressions are not influenced by culture but are universal across species. For example, a snarling expression with exposed teeth signals a threat in many animals, including humans. Darwin also suggested that displaying an emotion can intensify the feeling. Smiling, for example, could enhance one's sense of happiness. This idea laid the foundation for understanding the role...
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Related Experiment Video

Updated: Nov 24, 2025

Examining Online Syntactic Processing of Spoken Complex Sentences in Chinese Using Dual-Modal Interference Tasks
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Multiregional communication and the channel modulation hypothesis.

Bijan Pesaran1, Maureen Hagan2, Shaoyu Qiao1

  • 1Center for Neural Science, New York University, New York, NY 10003, USA.

Current Opinion in Neurobiology
|December 28, 2020
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Summary

Understanding multiregional communication is key to brain function and treating disorders. This study explores communication channel modulation for insights into brain networks and novel therapies.

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Area of Science:

  • Neuroscience
  • Cognitive Science
  • Systems Biology

Background:

  • Multiregional communication is crucial for complex behaviors and cognitive function.
  • Disordered brain communication is linked to neurological and neuropsychiatric conditions.
  • Recent advances allow for empirical testing of brain communication mechanisms.

Purpose of the Study:

  • To define multiregional communication using the concept of communication channel modulation.
  • To review behavioral and neurophysiological evidence supporting communication channel modulation.
  • To explore the implications of causal manipulations for developing novel therapies.

Main Methods:

  • Review of existing literature on multiregional communication.
  • Analysis of behavioral and neurophysiological data.
  • Discussion of causal manipulation techniques in neuroscience.

Main Results:

  • Communication channel modulation provides a framework for defining multiregional communication.
  • Evidence supports the modulation of communication channels in brain networks.
  • Causal manipulations offer a pathway for therapeutic development.

Conclusions:

  • Defining multiregional communication through channel modulation enhances understanding of brain networks.
  • Neurophysiological and behavioral evidence validates the concept of communication channel modulation.
  • Causal manipulations targeting multiregional communication hold promise for treating brain disorders.