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Denosumab Use as a Predictor Variable for External Cervical Resorption: A Case-Control Study.

Lolwa Alyahya1, Garry L Myers1

  • 1Department of Endodontics, Virginia Commonwealth University, Richmond, Virginia.

Journal of Endodontics
|December 28, 2020
PubMed
Summary

Denosumab use significantly increases the risk of developing external cervical resorption (ECR). This finding highlights a potential dental complication associated with this osteoporosis medication.

Keywords:
Denosumabbone turnoverexternal cervical resorptionidiopathic

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Area of Science:

  • Dentistry
  • Oral Medicine
  • Pharmacology

Background:

  • External cervical resorption (ECR) is a complex dental condition.
  • Understanding risk factors for ECR is crucial for prevention and management.

Purpose of the Study:

  • To investigate the association between denosumab use and the risk of developing external cervical resorption (ECR).

Main Methods:

  • A case-control study involving 33 patients diagnosed with ECR (cases) and matched controls.
  • Systemic and local factors, including denosumab use, were assessed as potential confounders.
  • Binary logistic regression analysis was employed to determine the association.

Main Results:

  • No significant baseline differences were found between case and control groups.
  • Denosumab use was significantly associated with an increased risk of ECR (OR = 7.317, P < .05) after adjusting for confounders.

Conclusions:

  • Denosumab use is a significant predictor for the development of external cervical resorption.
  • This suggests a potential link between denosumab therapy and ECR risk that warrants further clinical attention.