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PROSPECTS FOR CREATION OF RADIOPROTECTIVE MEANS BASED ON NATURAL POLYPHENOLS AND POLYSACCHARIDES
G N Voitenko1, A A Kalashnikov1, N V Kurdil1
1L. I. Medved's Scientific Center for Preventive Toxicology, Food and Chemical Safety of the Ministry of Health of Ukraine, Institute of Experimental Toxicology and Biomedical Research, 6 Heroiv Oborony St., Kyiv, 03680, Ukraine.
Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii
|December 28, 2020
Summary
Natural polyphenols, like quercetin, show promise as radioprotective agents. They effectively stimulate reparative regeneration in irradiated animals, suggesting potential for new radiation protection drugs.
Area of Science:
- Pharmacology and Toxicology
- Radiation Biology
- Natural Product Chemistry
Background:
- Modern threats from nuclear radiation necessitate novel pharmacological protection strategies.
- Natural polyphenols are of significant scientific interest for developing new radioprotective drugs and radiomodifiers.
Purpose of the Study:
- To evaluate the potential of plant polyphenolic substances (PPS) and their combinations with polysaccharides as radioprotective agents.
- To investigate the effects of quercetin and patulaten on reparative regeneration under X-ray irradiation and butadione suppression.
Main Methods:
- Experiments conducted on 130 male Wistar rats exposed to a total X-ray dose of 4.25 Gy.
- Assessed reparative regeneration in esophageal epithelium and skin wound healing following administration of PPS, quercetin, and pectin.
- Statistical analysis using Student's t-test (p < 0.05).
Main Results:
- Oral administration of PPS and pectin compositions, particularly quercetin granules, significantly enhanced reparative regeneration in esophageal epithelium (78.5% increase in mitotic index).
- Prophylactic administration and topical application of quercetin accelerated skin wound healing in irradiated rats.
- Quercetin demonstrated greatest efficiency when used both internally and topically.
Conclusions:
- Plant polyphenolic substances and polysaccharides show promise for developing radioprotective drugs.
- These agents can stimulate reparative regeneration processes, offering a new avenue for radiation protection therapies.
