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Acrocyanosis and digital necrosis are associated with poor prognosis in COVID-19

Guitti Pourdowlat1, Zohre Naderi2, Farhad Seif3,4

  • 1Chronic Respiratory Diseases Research Center National Research Institute of Tuberculosis and Lung Diseases Shahid Beheshti University of Medical Sciences Tehran Iran.

Clinical Case Reports
|December 28, 2020
PubMed

Insights

Acrocyanosis and digital necrosis in COVID-19 patients indicate microvascular issues and may predict outcomes. This microangiopathic and immunothrombosis phenomenon suggests broader organ involvement, impacting prognosis.

Area of Science:

  • Vascular Medicine
  • Immunology
  • Infectious Diseases

Background:

  • Microvascular dysfunction is increasingly recognized in severe infections.
  • Immunothrombosis plays a critical role in the pathophysiology of various diseases.

Observation:

  • Acrocyanosis and digital necrosis were observed in patients.
  • These findings are linked to microangiopathic and immunothrombosis phenomena.

Findings:

  • Microvascular involvement in acrocyanosis and digital necrosis can extend to other organs.
  • This microvascular complication has prognostic significance in COVID-19.

Implications:

  • Monitoring for peripheral vascular complications may aid in predicting COVID-19 severity.
  • Understanding immunothrombosis in COVID-19 is crucial for developing targeted therapies.

Keywords:
COVID‐19acrocyanosisdigital necrosisinterleukin‐6noradrenaline

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