Fiber optic endoscopic optical coherence tomography (OCT) to assess human airways: The relationship between anatomy...

Airway luminal area (A_i ) influences respiratory mechanics during dynamic exercise; however, previous studies have investigated the relationship between airway anatomy and physiological function in different groups of individuals. The purpose of this study was to determine the effect of A_i on respiratory mechanics by making in vivo measures of airway dimensions and work of breathing (Wb) in the same individuals. Healthy participants (3F/2M; 23-45 years) completed a cycle exercise test to exhaustion. During exercise, Wb was assessed using an esophageal balloon catheter, while simultaneously assessing minute ventilation ( $$_E ). On a separate day, subjects underwent a bronchoscopy procedure to capture optical coherence tomography (OCT) measures of three airways in the right lung. Each participant's Wb- $$_E data were fit to a non-linear regression equation (Wb = a $$_E³  + b $$_E² ) that partitions Wb into its turbulent resistive (a) and viscoelastic (b) components. Measures of A_i and luminal diameter were made for the 4th-6th airway generations. A composite index of airway size was calculated as the sum of the A_i for each generation and the total area of the 4th-6th generation was calculated based on Weibel's model. Constant a was significantly correlated to the Weibel model total airway area (r = -0.94, p = 0.017) and index of airway size (r = -0.929, p = 0.023), whereas constant b was not associated with either measure (both p > 0.05). We found that individuals who had the smallest A_i had the highest resistive Wb and our findings provide the basis for further study of the relationship between airway size and respiratory mechanics during exercise.