Risk of Venous Thromboembolism in Acute Necrotizing Pancreatitis: A Large Database Study
Dina S Ahmad1, Emad Mansoor2, Muhammed M Alikhan3
1From the Division of Gastroenterology, University of Tennessee Health Science Center, Memphis, TN.
Pancreas
|December 28, 2020
Summary
Acute necrotizing pancreatitis significantly increases the risk of venous thromboembolism (VTE) and mortality. This finding highlights the importance of VTE surveillance in patients with severe pancreatitis.
Area of Science:
- Gastroenterology
- Vascular Medicine
- Epidemiology
Background:
- Venous thromboembolism (VTE) incidence in acute pancreatitis (AP) is not well-established.
- Large-scale studies are needed to clarify the VTE risk associated with different AP classifications.
Purpose of the Study:
- To investigate the incidence of VTE in patients diagnosed with acute pancreatitis.
- To identify risk factors for VTE in AP, specifically comparing necrotizing and non-necrotizing forms.
Main Methods:
- Utilized a large electronic health record database (Explorys) for patient data from 2018-2019.
- Identified patients with acute necrotizing pancreatitis (ANP) and acute non-necrotizing pancreatitis (ANNP).
- Performed univariate and multivariate analyses to determine VTE incidence and associated risk factors.
Main Results:
- The VTE incidence was 7.1% in ANP versus 2.8% in ANNP (P < 0.001).
- ANP was independently associated with a 2.78-fold increased odds of VTE (P < 0.001).
- VTE in ANP cases correlated with significantly higher mortality (23.5% vs 15.9%, P < 0.001).
Conclusions:
- Acute necrotizing pancreatitis presents a substantially higher risk for VTE development compared to non-necrotizing AP.
- VTE in the context of ANP is linked to increased patient mortality, underscoring the severity of this complication.
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